Impact of MMP2, MMP9 and TIMP2 Gene Polymorphisms on Allograft Rejection in Pediatric Renal Transplant Recipients
نویسندگان
چکیده
منابع مشابه
Matrix metalloproteinase (MMP-9 and MMP-2) gene polymorphisms influence allograft survival in renal transplant recipients.
BACKGROUND Matrix metalloproteinases (MMPs), especially basement membrane-degrading MMP-9 and MMP-2, play an important role in immune-mediated tissue destruction of the allograft by allowing influx of leucocytes and mononuclear cells into the graft. The present study was, therefore, undertaken to investigate the association of functional polymorphisms in MMP-9 (836A>G, 1721G>C and 2003G>A) and ...
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OBJECTIVES To determine the utility of pre-implantation renal biopsy (PIB) to predict renal allograft outcomes. METHODS This is a retrospective review of all patients that underwent PIB from January 2003 to December 2011 at the Great Ormond Street Hospital for Children in London, United Kingdom. Thirty-two male patients (56%) aged 1.5-16 years (median: 10.2) at the time of transplantation wer...
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Previous international studies demonstrated significant heterogeneity in the tacrolimus (TAC) dose required to attain target blood concentrations, attributed to both genetic and ethnic factors. While the majority of previous reports on adult recipients of renal, heart and liver transplants have shown a significant effect of CYP3A5FNx013 single nucleotide polymorphisms (SNPs) on TAC pharmacokine...
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ژورنال
عنوان ژورنال: Transplantation
سال: 2018
ISSN: 0041-1337
DOI: 10.1097/01.tp.0000543696.43768.49